CTE risk, severity increases with years playing American football

The risk and severity of developing chronic traumatic encephalopathy (CTE) increases with the number of years playing American football according to a new study. These findings reaffirm the relationship between playing tackle football and CTE, and for the first time quantify the strength of that relationship.

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Scientists create brain-mimicking environment to grow 3D tissue models of brain tumors

Researchers have developed 3-dimensional human tissue culture models of pediatric and adult brain cancers in a brain-mimicking microenvironment, that includes brain-derived extracellular matrix (ECM) — the complex network of proteins and amino acids with bound sugars that not only provides support for surrounding neural tissue, but also helps to guide cell growth and development. The development represents a significant advancement for the study of brain tumor biology and pharmacological response.

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Mounting brain organoid research reignites ethical debate

As research involving the transplantation of human 'mini-brains' — known as brain organoids — into animals to study disease continues to expand, so do the ethical debates around the practice. A new article seeks to clarify the abilities of brain organoids and suggests an ethical framework that better defines and contextualizes these organoids and establishes thresholds for their use.

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Pesticides likely caused 'Havana syndrome' that affected Cuba-based diplomats

The study details the nature of the injury, specifies the brain regions involved, including the blood-brain barrier and suggests a possible cause in the form of 'cholinesterase inhibitors,' with 'organophosphorus insecticides' being a likely source. Cholinesterase (ChE) is one of the key enzymes required for the proper functioning of the nervous systems of humans, invertebrates and insects.

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