Brain mechanisms have potential to block arthritis pain

Because pain is a complex condition, treating it efficiently continues to pose challenge for physicians. Past pain research typically has focused upon the spinal cord or the peripheral areas of the nervous system located outside the spinal cord and brain. However, a research team recently investigated how some mechanisms in the brain contribute to pain.

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New method visualizes groups of neurons as they compute

Using a fluorescent probe that lights up when brain cells are electrically active, researchers found they can image the activity of many neurons at once, in mice brains. The technique could allow neuroscientists to analyze circuits within the brain and link them to specific behaviors.

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Scientists find gender-distinct circuit for depression

Depression affects women nearly twice as much as men, but unraveling the brain's blueprint that regulates this behavior, let alone identifying specific molecular differences between sexes, has proven difficult. Researchers, however, have found and flipped a switch in the brain, revealing a single circuit in mice that activates during stress and is controlled by testosterone.

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Scientists create brain-mimicking environment to grow 3D tissue models of brain tumors

Researchers have developed 3-dimensional human tissue culture models of pediatric and adult brain cancers in a brain-mimicking microenvironment, that includes brain-derived extracellular matrix (ECM) — the complex network of proteins and amino acids with bound sugars that not only provides support for surrounding neural tissue, but also helps to guide cell growth and development. The development represents a significant advancement for the study of brain tumor biology and pharmacological response.

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