Autoantibodies in pregnancy: A cause of behavioral disorders in the child?
Dysfunctions in the maternal immune system that occur during pregnancy could possibly lead to impaired brain development in the unborn child.
Read moreBirth Defects
Clues to the origin of Huntington's disease, and a new way to find drugs
Using a new technique to study brain development, scientists were able to trace the causes of Huntington's back to early developmental stages when the brain has only just begun to form.
Read morePotential target for cardiac fibrosis treatment
A research team has identified a potential target for treating heart failure related to fibrosis. The study looked at an epigenetic 'reader' protein known as BRD4, showing that it serves a central role in regulating the activation of cardiac fibroblasts. They also found that chemical inhibitors of BRD4 potently block cardiac fibroblast activation.
Read moreDefective cilia linked to heart valve birth defects
Bicuspid aortic valve (BAV), the most common heart valve birth defect, is associated with genetic variation in human primary cilia during heart valve development, report researchers. Crucial to cilia development is the exocyst, which shuttles cilia cargo to the cell membrane. Disrupting the exocyst impaired ciliogenesis and caused a spectrum of cardiac defects in zebrafish and BAV in mice.
Read moreDeaths halved among infarct patients attending Heart School
Patients who attend 'Heart School', as almost every patient in Sweden is invited to do after a first heart attack, live longer than non-participating patients.
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