New fluorescence method reveals signatures of individual microbes

Researchers have developed a new method that reveals the unique fluorescence patterns produced by individual cells in mixtures of bacteria, yeast and fungi. They combined confocal microscopy with micro-spectroscopy to determine the fluorescence signatures from different types of microbes. They trained machine learning systems to analyze the images and identify different individual cells and cell-types automatically, even those with very similar shapes and sizes.

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Identifying a gene for canine night blindness

Researchers have identified the gene mutation responsible for a form of night blindness in dogs. Strategies to treat this condition, which affects a layer of neurons just below the primary photoreceptor cells, could also inform treatment of other diseases that rely on targeting this cell type.

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How AIDS pathogens multiply in the body

Scientists have now succeeded in using high-resolution imaging to make visible to the millisecond how the HI virus spreads between living cells and which molecules it requires for this purpose. The researchers provide direct proof for the first time that the AIDS pathogen creates a certain lipid environment for replication.

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