Deep inside the brain: Unraveling the dense networks in the cerebral cortex

Mammalian brains, with their unmatched number of nerve cells and density of communication, are the most complex networks known. While methods to analyze neuronal networks sparsely have been available for decades, the dense mapping of neuronal circuits is a major scientific challenge. Researchers have now succeeded in the dense connectomic mapping of brain tissue from the cerebral cortex, and quantify the possible imprint of learning in the circuit.

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Spotting cutting-edge topics in scientific research using keyword analysis

Researchers have conducted a quantitative keyword analysis of 30 million articles in the life sciences over a nearly fifty-year period (1970-2017) and found that 75% of total emerging keywords, at 1-year prior to becoming identified as emerging, co-appeared with other emerging keywords in the same article.

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Newly discovered protein is the permit to the powerhouse of cells

Researchers report the discovery of a protein, P17/PERMIT, that is key to recycling aging and damaged mitochondria. Defective mitochondria are characteristic of a number of age-related diseases, including cancer and Alzheimer's. The MUSC team showed P17/PERMIT transports the machinery that produces ceramide, a molecule that signals old mitochondria for destruction, to the mitochondria. There, it can mass-produce ceramide at the location needed for mitochondrial regulation.

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Protein movement in cells hints at greater mysteries

A new imaging technique that makes it possible to match motor proteins with the cargo they carry within a cell is upending a standard view of how cellular traffic reaches the correct destination. The research focuses on neurons and sheds light on some neurodegenerative diseases.

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Special cells contribute to regenerate the heart in Zebrafish

It is already known that zebrafish can flexibly regenerate their hearts after injury. An international research group now shows that certain heart muscle cells play a central role in this process. The insights gained could be used to initiate a similar repair process in the human heart.

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A marine pathogenic bacterium forms specialized cells for dissemination

Vibrio parahaemolyticus can be found in the tidal zones in estuarine areas. The marine bacterium causes acute gastroenteritis in humans and is the leading cause for seafood borne illnesses in the world. Researchers have now identified specialized "adventurer" cells that ensure the bacterium's dissemination and prevalence. Their new findings are an important basis for the future management of the disease.

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