Genome-edited bull passes on hornless trait to calves

For the past two years, researchers have been studying six offspring of a dairy bull, genome-edited to prevent it from growing horns. Scientists report that none of the bull's offspring developed horns, as expected, and blood work and physical exams of the calves found they were all healthy. The researchers also sequenced and analyzed the genomes of the calves and their parents looking for any unexpected changes.

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Weak spot in pathogenic bacteria

Antibiotics are still the most important weapon for combatting bacterial infections. But medical science is running out of ''ammunition'' because of more and more frequently occurring resistances. Research teams have now elucidated the structure of the proteolytic complex ClpX-ClpP. This is a key to development of innovative antibiotics which target the degradation process of defective proteins in bacteria.

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New defensive mechanism against bacterial wound infections

Wound inflammation which results in impaired wound healing can have serious consequences for patients. Researchers have discovered a new defensive mechanism which enables our skin to actively kill bacteria. Central to this mechanism is a cellular messenger molecule known as 'interleukin 6', whose mode of action may be used in the future to prevent wound infections.

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Antibiotic resistant genes prevalent in groundwater

The spread of antibiotic resistant genes (ARGs) through the water system could put public safety at-risk. Researchers studied and compared samples from an advanced groundwater treatment facility in California and groundwater aquifers to detect differences in ARG concentrations. They found that the advanced groundwater treatment facility reduced nearly all targeted ARGs to below detection limits, but groundwater samples had a ubiquitous presence of ARGs in both control locations and locations recharged with water from the advanced water treatment facility.

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Engineered viruses could fight drug resistance

Biological engineers can program bacteriophages to kill different strains of E. coli by making mutations in the protein that the viruses use to bind to host cells. These engineered phages are less likely to provoke resistance in bacteria, and could help to overcome antibiotic resistance.

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Gut bacteria 'fingerprint' predicts radiotherapy side effects

Taking a 'fingerprint' of the mix of bacteria in the gut can indicate how susceptible individual cancer patients are to gut damage as a result of radiotherapy for prostate and gynaecological cancers, a new study shows. Researchers showed that having a reduced diversity of gut bacteria was associated with an increased risk of both immediate and delayed damage to the gut following radiotherapy.

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