Researchers quantify Cas9-caused off-target mutagenesis in mice

Scientists are finding new ways to improve the use of the CRISPR enzyme Cas9 and reduce the chances of off-target mutations in laboratory mice, according to new results. The findings will help scientists contextualize a common concern related to gene editing and identify new strategies to improve its precision.

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Limiting mealtimes may increase your motivation for exercise

Limiting access to food in mice increases levels of the hormone, ghrelin, which may also increase motivation to exercise, according to a new study. The study suggests that a surge in levels of appetite-promoting hormone, ghrelin, after a period of fasting prompted mice to initiate voluntary exercise.

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SNAP provides a model for ensuring a right to food

Alleviating food insecurity is often seen as one of the fundamental roles a country should fulfill. The Supplemental Nutrition Assistance Program (SNAP) is effective in addressing the right to food in the US, and that the program can serve as an example for countries that struggle to provide food for all citizens.

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Land management practices to reduce nitrogen load may be affected by climate changes

Nitrogen from agricultural production is a major cause of pollution in the Mississippi River Basin and contributes to large dead zones in the Gulf of Mexico. Illinois and other Midwestern states have set goals to reduce nitrogen load through strategies that include different land management practices. A new study uses computer modeling to estimate how those practices may be affected by potential changes in the climate, such as increased rainfall.

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Atmospheric pressure impacts greenhouse gas emissions from leaky oil and gas wells

Fluctuations in atmospheric pressure can heavily influence how much natural gas leaks from wells below the ground surface at oil and gas sites, according to new research. However, current monitoring strategies do not take this phenomenon into account, and therefore may be under- or over-estimating the true magnitude of gas emissions.

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Novel nanoprobes show promise for optical monitoring of neural activity

Researchers have developed ultrasensitive nanoscale optical probes to monitor the bioelectric activity of neurons and other excitable cells. This novel readout technology could enable scientists to study how neural circuits function at an unprecedented scale by monitoring large numbers of individual neurons simultaneously. It could also lead to high-bandwidth brain-machine interfaces with dramatically enhanced precision and functionality.

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Young adults with PTSD may have a higher risk of stroke in middle age

Young adults who develop PTSD after a traumatic event (e.g., gun violence, sexual assault, military combat or natural disaster) may be more likely to experience a transient ischemic attack (TIA) or major stroke event by middle age. This nationwide study of more than 1.1 million adults showed that PTSD may be a potent risk factor for developing stroke at a young age.

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Wind turbine design and placement can mitigate negative effect on birds

Wind energy is increasingly seen as a sustainable alternative to fossil fuels, as it contributes to a reduction in greenhouse gas emissions. However, the rapid expansion of wind farms has raised concerns about the impact of wind turbines on wildlife. A new study provides comprehensive data on how turbines affect bird populations. The study suggests ways to mitigate negative effects through wind turbine design and placement, recommending taller turbines, shorter blades, and placement away from bird habitats.

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