Resistance to last resort drug arose in patient over 3 weeks

French investigators have described development of resistance to one of the last resort therapies used to treat extremely drug-resistant Pseudomonas aeruginosa. That resistance arose in a single patient over a scant 22 days. They subsequently identified the single nucleotide mutation in P. aeruginosa that caused the resistance.

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Unique brain changes in people with Huntington's disease

The part of the brain that selectively degenerates in people with Huntington's disease (HD), called the striatum, is almost entirely destroyed in the late stages of the disease. Brain samples from mutant HD gene positive individuals who had not yet developed symptoms by time of death are extremely rare. As a consequence, very little is known about the active disease process that causes the devastating symptoms of HD.

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Defining the centromere

Centromeres are the chromosomal domains at which the kinetochore, a protein complex required for the correct separation of chromosomes during mitosis and meiosis, is assembled. The incorporation of the histone variant CenH3 into centromeric nucleosomes is a prerequisite for the proper assembly and function of the kinetochore. A new study describes the chaperone protein NASPSIM3 and how it affects the depositioning of CenH3.

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