A Matter of concentration

Using the model plant Arabidopsis thaliana, or mouse-ear cress, the scientists have researched how the concentration of Argonaute proteins affects the ratio of stem cells to differentiated cells, such as flower or leaf cells. The Argonaute proteins AGO1 and ZLL/AGO10 are key factors in RNA interference, a process in which the transfer of genetic information is inhibited. Because AGO1 destroys messenger RNA, which are vital for the maintenance of stem cells, this promotes cell differentiation — in other words, their development into specialized cell types. Laux’s research group has discovered that the exact opposite occurs when there is a high concentration of AGO1. In this case, the protein protects the messenger RNA from degrading and prevents the cells from differentiating, promoting the maintenance of stem cells.

As a result, the scientists have demonstrated that the balance between stem cells and differentiated cells depends on the exact concentration of Argonaute proteins — and that the activity of these proteins is completely reversed when their concentration exceeds a certain level. This means that scientists could use these proteins in biotechnology to cultivate stem cells or to develop organs — for example, a small number of cultivated stem cells could be used to reproduce plants that are able to better adapt to changes in the environment.

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